Open AccessAge of the Donor Reduces the Ability of Human Adipose‐Derived Stem Cells to Alleviate Symptoms in the Experimental Autoimmune Encephalomyelitis Mouse Model
Author(s) -
Scruggs Brittni A.,
Semon Julie A.,
Zhang Xiujuan,
Zhang Shijia,
Bowles Annie C.,
Pandey Amitabh C.,
Imhof Kathleen M.P.,
Kalueff Allan V.,
Gimble Jeffrey M.,
Bunnell Bruce A.
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0026
Subject(s) - remyelination , mesenchymal stem cell , medicine , experimental autoimmune encephalomyelitis , multiple sclerosis , stem cell , immunology , myelin , cell therapy , pathology , central nervous system , biology , genetics
In a mouse model, human adipose‐derived mesenchymal stem cells from older donors failed to ameliorate the neurodegeneration associated with experimental autoimmune encephalomyelitis, and mice treated with cells from older donors had increased central nervous system inflammation, demyelination, and splenocyte proliferation. The age‐related therapeutic differences corroborate recent findings that biologic aging occurs in stem cells.