Open AccessProgranulin, a Major Secreted Protein of Mouse Adipose‐Derived Stem Cells, Inhibits Light‐Induced Retinal Degeneration
Author(s) -
Tsuruma Kazuhiro,
Yamauchi Mika,
Sugitani Sou,
Otsuka Tomohiro,
Ohno Yuta,
Nagahara Yuki,
Ikegame Yuka,
Shimazawa Masamitsu,
Yoshimura Shinichi,
Iwama Toru,
Hara Hideaki
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0020
Subject(s) - retinal , microbiology and biotechnology , retinal degeneration , outer nuclear layer , adipose tissue , retina , biology , photoreceptor cell , neuroprotection , stem cell , chemistry , endocrinology , biochemistry , pharmacology , neuroscience
The authors examined the protective effects of adipose‐derived stem cells and adipose‐derived stem cell‐conditioned medium (ASC‐CM) against retinal damage and identified the neuroprotective factors in ASC‐CM. The findings suggest that ASC‐CM and progranulin have neuroprotective effects in the light‐induced retinal‐damage model. Progranulin may be a potential target for the treatment of the degenerative diseases of the retina.