Open AccessAdipose‐Derived Mesenchymal Stromal Cells From Aged Patients With Coronary Artery Disease Keep Mesenchymal Stromal Cell Properties but Exhibit Characteristics of Aging and Have Impaired Angiogenic Potential
Author(s) -
Efimenko Anastasia,
Dzhoyashvili Nina,
Kalinitalia,
Kochegura Tatiana,
Akchurin Renat,
Tkachuk Vsevolod,
Parfyonova Yelena
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0014
Subject(s) - mesenchymal stem cell , stromal cell , adipose tissue , medicine , coronary artery disease , cancer research , disease , cardiology , pathology
This study analyzed how patient age affected the angiogenic properties of adipose‐derived mesenchymal stromal cells (ADSCs). ADSCs from aged patients both with and without coronary artery disease acquire aging characteristics, and their angiogenic potential declines because of decreasing proangiogenic factor secretion. This could restrict the effectiveness of autologous cell therapy with ADSCs in aged patients.