Genetically Modified Neural Stem Cells for a Local and Sustained Delivery of Neuroprotective Factors to the Dystrophic Mouse Retina | Zendy

Jung Gila | Zendy; Sun Jing | Zendy; Petrowitz Bettina | Zendy; Riecken Kristoffer | Zendy; Kruszewski Katharina | Zendy; Jankowiak Wanda | Zendy; Kunst Frank | Zendy; Skevas Christos | Zendy; Richard Gisbert | Zendy; Fehse Boris | Zendy; Bartsch Udo | Zendy

Open Access

Genetically Modified Neural Stem Cells for a Local and Sustained Delivery of Neuroprotective Factors to the Dystrophic Mouse Retina

Author(s) -

Jung Gila,

Sun Jing,

Petrowitz Bettina,

Riecken Kristoffer,

Kruszewski Katharina,

Jankowiak Wanda,

Kunst Frank,

Skevas Christos,

Richard Gisbert,

Fehse Boris,

Bartsch Udo

Publication year - 2013

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2013-0013

Subject(s) - ciliary neurotrophic factor , retinitis pigmentosa , retina , gene delivery , biology , retinal degeneration , microbiology and biotechnology , stem cell , neural stem cell , neurotrophic factors , neuroprotection , cell culture , neuroscience , transfection , genetics , receptor

In two mouse models of retinitis pigmentosa, intravitreal transplantations of adherently cultivated neural stem cells that had been modified to secrete ciliary neurotrophic factor resulted in a sustained delivery of functionally relevant quantities of the cytokine to the dystrophic retina. These transplantations may thus represent a useful method for preclinical studies aimed at evaluating the therapeutic potential of a cell‐based administration of neurotrophic factors in mouse models of photoreceptor degeneration.

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