Open AccessGenetically Modified Neural Stem Cells for a Local and Sustained Delivery of Neuroprotective Factors to the Dystrophic Mouse Retina
Author(s) -
Jung Gila,
Sun Jing,
Petrowitz Bettina,
Riecken Kristoffer,
Kruszewski Katharina,
Jankowiak Wanda,
Kunst Frank,
Skevas Christos,
Richard Gisbert,
Fehse Boris,
Bartsch Udo
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0013
Subject(s) - ciliary neurotrophic factor , retinitis pigmentosa , retina , biology , gene delivery , retinal degeneration , microbiology and biotechnology , neuroprotection , neurotrophic factors , muller glia , stem cell , neural stem cell , cell culture , neuroscience , progenitor cell , transfection , genetics , receptor
In two mouse models of retinitis pigmentosa, intravitreal transplantations of adherently cultivated neural stem cells that had been modified to secrete ciliary neurotrophic factor resulted in a sustained delivery of functionally relevant quantities of the cytokine to the dystrophic retina. These transplantations may thus represent a useful method for preclinical studies aimed at evaluating the therapeutic potential of a cell‐based administration of neurotrophic factors in mouse models of photoreceptor degeneration.