Open AccessNestin Expression in End‐Stage Disease in Dystrophin‐Deficient Heart: Implications for Regeneration From Endogenous Cardiac Stem Cells
Author(s) -
Berry Suzanne E.,
Andruszkiewicz Peter,
Chun Ju Lan,
Hong Jun
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0174
Subject(s) - dystrophin , nestin , utrophin , biology , stem cell , duchenne muscular dystrophy , desmin , myocyte , cardiac marker , pathology , microbiology and biotechnology , medicine , vimentin , neural stem cell , immunology , troponin , immunohistochemistry , myocardial infarction , genetics
This study examined nestin‐positive stem cells in myocardium of dystrophin/utrophin‐deficient mice, a model for Duchenne muscular dystrophy. Findings indicate that new cardiomyocytes form in dystrophic heart, and nestin‐positive interstitial cells may generate them in addition to other cells of the cardiac lineage.