Open AccessConcise Review: Adult Mesenchymal Stem Cells, Adult Neural Crest Stem Cells, and Therapy of Neurological Pathologies: A State of Play
Author(s) -
Neirinckx Virginie,
Coste Cécile,
Rogister Bernard,
Wislet-Gendebien Sabine
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0147
Subject(s) - mesenchymal stem cell , stem cell , neural crest , neural stem cell , adult stem cell , stem cell therapy , biology , stem cell transplantation for articular cartilage repair , pathology , medicine , neuroscience , clinical uses of mesenchymal stem cells , cellular differentiation , immunology , microbiology and biotechnology , genetics , embryo , gene
The ability of adult mesenchymal stem cells (MSCs) and neural crest stem cells (NCSCs) to integrate and differentiate into neurons once inside the central nervous system is currently questioned. For this review, exhaustive data were collected on MSC/NCSC neural differentiation in vitro. Preclinical cell therapy experiments were then analyzed in different models for neurological diseases, and it was concluded that neural differentiation is probably not the leading property of adult MSCs and NCSCs concerning neurological pathology management.