Open AccessHumanized Culture of Periosteal Progenitors in Allogeneic Serum Enhances Osteogenic Differentiation and In Vivo Bone Formation
Author(s) -
Roberts Scott J.,
Owen Helen C.,
Tam Wai Long,
Solie Lien,
Van Cromphaut Sophie J.,
Van den Berghe Greet,
Luyten Frank P.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0137
Subject(s) - progenitor cell , microbiology and biotechnology , runx2 , fetal bovine serum , alkaline phosphatase , stem cell , chemistry , bone resorption , immunology , biology , cell , endocrinology , biochemistry , enzyme
The authors attempted to apply alternative, xeno‐free culturing practices to a bone‐forming combination product of human periosteal progenitors on a clinically used calcium phosphate carrier. This study highlights the advantages of using humanized culture conditions for the expansion of human periosteal progenitors intended for bone regeneration.