Open AccessSafety of Epicenter Versus Intact Parenchyma as a Transplantation Site for Human Neural Stem Cells for Spinal Cord Injury Therapy
Author(s) -
Piltti Katja M.,
Salazar Desirée L.,
Uchida Nobuko,
Cummings Brian J.,
Anderson Aileen J.
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0110
Subject(s) - transplantation , spinal cord injury , neural stem cell , medicine , spinal cord , central nervous system , stem cell , parenchyma , pathology , biology , surgery , microbiology and biotechnology , psychiatry
This study compared transplantation into the spinal cord injury (SCI) epicenter (EPI) versus intact rostral/caudal (R/C) parenchyma in contusion‐injured athymic nude rats and assessed the survival, differentiation, and migration of human central nervous system‐derived neural stem cells (hCNS‐SCns). Regardless of transplantation site, hCNS‐SCns survived and proliferated; however, the total number of hCNS‐SCns quantified in the R/C transplant animals was twice that in the EPI animals, demonstrating increased overall engraftment. Findings suggest that the intact parenchyma may be a more favorable transplantation site than the injury epicenter in the subacute period post‐SCI.