Open AccessConcise Review: Preleukemic Stem Cells: Molecular Biology and Clinical Implications of the Precursors to Leukemia Stem Cells
Author(s) -
Pandolfi Ashley,
Barreyro Laura,
Steidl Ulrich
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0109
Subject(s) - stem cell , haematopoiesis , biology , myeloid leukemia , leukemia , somatic evolution in cancer , epigenetics , progenitor cell , myelodysplastic syndromes , myeloid , cancer research , immunology , genetics , bone marrow , cancer , gene
Despite the established use of poly‐chemotherapy, relapse continues to be the most common cause of death in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The therapeutic elimination of all leukemia stem cells (LSC) and pre‐LSC will be essential for achieving lasting cures. This article reviews recent and ongoing advances in understanding the roles of pre‐LSC, and the aberrations that lead to pre‐LSC formation and subsequent LSC transformation.