Open AccessCord Blood Transplantation for Cure of HIV Infections
Author(s) -
Petz Lawrence
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0089
Subject(s) - cord blood , medicine , transplantation , human leukocyte antigen , immunology , hematopoietic stem cell transplantation , bone marrow , haematopoiesis , stem cell , antigen , biology , genetics
HIV infection has been cured by a hematopoietic cell transplantation (HCT) using peripheral blood stem cells from an adult donor homozygous for CCR5 ‐Δ32, but this approach cannot be readily generalized because of the low prevalence of the CCR5 ‐Δ32 allele and the need for a very close human leukocyte antigen (HLA) match between adult donors and recipients. Cord blood (CB) transplantation does not require as stringent an HLA match between donor and recipient, and therefore cryopreserved homozygous CCR5 ‐Δ32 CB units provide a feasible means to potentially cure reasonable numbers of patients who are infected with HIV. CB units are being screened to develop an inventory of cryopreserved homozygous CCR5 ‐Δ32 units available for HCT.