Open AccessSubventricular Zone‐Derived Neural Stem Cell Grafts Protect Against Hippocampal Degeneration and Restore Cognitive Function in the Mouse Following Intrahippocampal Kainic Acid Administration
Author(s) -
Miltiadous Panagiota,
Kouroupi Georgia,
Stamatakis Antonios,
Koutsoudaki Paraskevi N.,
Matsas Rebecca,
Stylianopoulou Fotini
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0074
Subject(s) - neural stem cell , neuroprotection , kainic acid , transplantation , hippocampal formation , astrogliosis , neuroscience , subgranular zone , subventricular zone , neurodegeneration , cognitive decline , granule cell , biology , hippocampus , morris water navigation task , hippocampal sclerosis , stem cell , epilepsy , medicine , dentate gyrus , temporal lobe , microbiology and biotechnology , central nervous system , glutamate receptor , dementia , receptor , disease , biochemistry
This study investigated the therapeutic potential of neural stem/precursor cells (NSCs), naïve or transduced with a lentiviral vector for overexpression of insulin‐like growth factor I (IGF‐I), after transplantation in a mouse model of kainic acid (KA)‐induced hippocampal degeneration, which represents an animal model of temporal lobe epilepsy. Exposure of mice to the Morris water maze task revealed that unilateral intrahippocampal NSC transplantation significantly prevented the KA‐induced cognitive decline. The results demonstrate that transplantation of IGF‐I producing NSCs is neuroprotective and restores cognitive function following KA‐induced hippocampal degeneration.