Open AccessHuman Mesenchymal Stem Cell Grafts Enhance Normal and Impaired Wound Healing by Recruiting Existing Endogenous Tissue Stem/Progenitor Cells
Author(s) -
Shin Laura,
Peterson Daniel A.
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0041
Subject(s) - mesenchymal stem cell , wound healing , progenitor cell , stem cell , medicine , cancer research , immunology , endothelial stem cell , endothelial progenitor cell , pathology , microbiology and biotechnology , biology , in vitro , biochemistry
This study evaluated the relative contribution of grafted human mesenchymal stem cells (hMSCs) and host stem/progenitor cells in promoting wound healing by using a novel asymmetric wound model in normal and impaired healing diabetic ( db/db ) mice to discriminate between the effect of direct engraftment and the subsequent systemic response. Grafted hMSCs significantly improved healing in both normal and impaired healing animals; produced significant elevation of signals such as Wnt3a, vascular endothelial growth factor, and platelet‐derived growth factor receptor‐α; and increased the number of pre‐existing host MSCs recruited to the wound bed. The study validates that hMSCs evoke a host response that is clinically relevant, and it is suggested that therapeutic efforts should focus on maximizing the mobilization of host MSCs.