Open AccessAngiogenic Dysfunction in Bone Marrow‐Derived Early Outgrowth Cells from Diabetic Animals Is Attenuated by SIRT1 Activation
Author(s) -
Yuen Darren A.,
Zhang Yanling,
Thai Kerri,
Spring Christopher,
Chan Lauren,
Guo Xiaoxin,
Advani Andrew,
Sivak Jeremy M.,
Gilbert Richard E.
Publication year - 2012
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0026
Subject(s) - cxcl1 , bone marrow , angiogenesis , chemokine , endothelial dysfunction , diabetes mellitus , ex vivo , immunology , in vivo , cancer research , medicine , neovascularization , endocrinology , biology , microbiology and biotechnology , inflammation
The study was designed to determine whether diabetes‐associated early outgrowth cell (EOC) dysfunction might be attenuated by pharmacological activation of silent information regulator protein 1 (SIRT1), a lysine deacetylase implicated in nutrient‐dependent life span extension in mammals. The findings suggest that the impaired angiogenicity of EOCs in diabetes may be a consequence of a reduction in SIRT1 and that its activation may represent a novel therapeutic strategy to augment endothelial repair in this disease.