Open AccessTranslation of Stem Cell Research: Points to Consider in Designing Preclinical Animal Studies
Author(s) -
Frey-Vasconcells Joyce,
Whittlesey Kevin J.,
Baum Elona,
Feigal Ellen G.
Publication year - 2012
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0018
Subject(s) - stem cell , translation (biology) , translational research , preclinical research , computational biology , biology , bioinformatics , computer science , microbiology and biotechnology , genetics , messenger rna , gene
This article outlines important parameters to guide the design of preclinical studies for stem cell‐based therapeutics and reviews the types of preclinical studies that should be considered. Considerations in the design and execution of specific studies to monitor the efficacy, toxicity, biodistribution, and tumorigenicity of stem cell‐based therapeutics are also discussed.