Open AccessBioengineered Myocardium Derived from Induced Pluripotent Stem Cells Improves Cardiac Function and Attenuates Cardiac Remodeling Following Chronic Myocardial Infarction in Rats
Author(s) -
Miki Kenji,
Uenaka Hisazumi,
Saito Atsuhiro,
Miyagawa Shigeru,
Sakaguchi Taichi,
Higuchi Takahiro,
Shimizu Tatsuya,
Okano Teruo,
Yamanaka Shinya,
Sawa Yoshiki
Publication year - 2012
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2011-0038
Subject(s) - myocardial infarction , medicine , cardiology , ventricular remodeling , cardiac function curve , induced pluripotent stem cell , heart failure , stem cell , ligation , immunostaining , infarction , biology , immunohistochemistry , embryonic stem cell , microbiology and biotechnology , biochemistry , gene
Cardiac tissue sheets, termed bioengineered myocardium (BM), were developed from mouse iPS cells, and cardiac performance was measured following BM implantation in a rat chronic myocardial infarction model. The implanted BM survived and attenuated left ventricular remodeling in the rat chronic myocardial infarction model. Thus, BM derived from induced pluripotent stem cells might be a promising new treatment for heart failure.