Open AccessAssociations of galectin-3 expression and LGALS-3 (rs4652) gene variant with coronary artery disease risk in diabetics
Author(s) -
Basma Ibrahim,
Samy Hassanin Mohamed,
Mohamed M M Hassaan,
Norhan A. Sabbah
Publication year - 2021
Publication title -
journal of medical biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.681
H-Index - 17
eISSN - 1452-8258
pISSN - 1452-8266
DOI - 10.5937/jomb0-30424
Subject(s) - coronary artery disease , genotype , type 2 diabetes mellitus , allele , galectin 3 , medicine , polymerase chain reaction , gene , diabetes mellitus , biology , immunology , microbiology and biotechnology , endocrinology , genetics
Galectin-3 protein encoded by lectin galactoside-binding soluble-3 (LGALS-3) gene is an important genetic factor in type 2 diabetes mellitus (T2DM) and its cardiovascular obstacles in various populations. We aimed to elicit the pro-inflammatory effect of galectin-3 as determined by interleukin-6 (IL-6) serum levels and to explore the relationship between galectin-3 (LGALS-3 rs4652) gene variant and its expression levels with coronary artery disease (CAD) risk among T2DM Egyptian patients.