Open AccessProtein tyrosine kinases: challenges in the development of drugs aimed at cancer therapy
Author(s) -
Carolina M. Avila,
Nelilma C. Romeiro
Publication year - 2010
Publication title -
revista virtual de química
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.209
H-Index - 14
ISSN - 1984-6835
DOI - 10.5935/1984-6835.20100007
Subject(s) - protein tyrosine kinases , cancer , tyrosine kinase , cancer therapy , kinase , receptor tyrosine kinase , cancer research , medicine , tyrosine , pharmacology , computational biology , biology , biochemistry , receptor
This paper describes recent information on protein tyrosine kinases and their importance as molecular targets in cancer therapy, as well as the challenges involved in selective binding of drugs while overcoming resistance. Special attention is given to X-ray diffraction studies of enzyme-inhibitor co-crystals, which have demonstrated new binding modes of the second generation of anticancer drugs, tyrosine kinase inhibitors. DOI: 10.5935/1984-6835.20100007Este trabalho descreve informações recentes sobre as proteínas tirosinas quinases e sua importância como alvos moleculares na terapia do câncer. Atenção especial é dada aos estudos de difração de raios-X de complexos inibidores-enzimas que elucidaram novos modos de ligação da segunda geração de fármacos anticâncer, inibidores de tirosinas quinases. DOI: 10.5935/1984-6835.2010000