Open AccessSpectaline, cassine and semi-synthetic analogues as potential candidate drugs for the treatment of Alzheimer disease
Author(s) -
Dulce Helena Siqueira Silva,
Cláudio Viegas,
Luciana Ávila Santos,
Ian CastroGamboa,
Alberto José Cavalheiro,
Vanderlan S. Bolzani,
Newton G. Castro,
Marcos Pivatto,
Maria Cláudia Marx Young,
Mariana C. Rocha,
Carlos A. M. Fraga,
Eliezer J. Barreiro
Publication year - 2010
Publication title -
revista virtual de química
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.209
H-Index - 14
ISSN - 1984-6835
DOI - 10.5935/1984-6835.20100005
Subject(s) - disease , alzheimer's disease , medicine , neuroscience , pharmacology , psychology
Este artigo descreve o estudo fitoquímico de Senna spectabilis que conduziu ao isolamento de espectalina, cassina e outros alcaloides piperidínicos, a obtenção de análogos semi-sintéticos da espectalina e cassina, e a avaliação de suas propriedades farmacológicas e toxicológicas que resultaram no estabelecimento de dois candidatos a fármacos para o tratamento da doença de Alzheimer (DA). DOI: 10.5935/1984-6835.20100005This paper describes the main steps in the study of Senna spectabilis, as part of our bioprospection studies, with the isolation of spectaline, cassine and other piperidine alkaloids, as well as the preparation of semi-synthetic analogues, and the studies of their pharmacological and toxicological properties, which led to the establishment of two candidate drugs for the treatment of Alzheimer disease. DOI: 10.5935/1984-6835.2010000