Total synthesis of (-)-oseltamivir by domino reactions | Zendy

Fernando de Carvalho da Silva | Zendy

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Total synthesis of (-)-oseltamivir by domino reactions

Author(s) -

Fernando de Carvalho da Silva

Publication year - 2009

Publication title -

revista virtual de química

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.209

H-Index - 14

ISSN - 1984-6835

DOI - 10.5935/1984-6835.20090010

Subject(s) - domino , medicine , oseltamivir , domino effect , virology , chemistry , covid-19 , political science , organic chemistry , law , catalysis , disease , infectious disease (medical specialty)

Esta resenha é sobre a síntese total do (-)-oseltamivir, recentemente publicada por Ishikawa e colaboradores na revista Angewandte Chemie, International Edition. Essa substância é o princípio ativo do medicamento Tamiflu®, poderoso inibidor da enzima neuramidase do vírus da gripe aviária H5N1. Fonte: Ishikawa, H.; Suzuki, T.; Hayashi, Y. Angew. Chem. Int. Ed. 2009, 48, 1304. [CrossRef] DOI: 10.5935/1984-6835.20090010 This digest report the total synyhesis of (-)-oseltamivir (Tamiflu®) by three “one-pot” operations like domino reactions. This article was published by Ishikawa e co-workers in Angewandte Chemie, International Edition. This molecule is a neuraminidase inhibitor used in the treatment against avian H5N1 influenza virus. Source: Ishikawa, H.; Suzuki, T.; Hayashi, Y. Angew. Chem. Int. Ed. 2009, 48, 1304. [CrossRef] DOI: 10.5935/1984-6835.2009001

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