Open AccessTotal synthesis of (-)-oseltamivir by domino reactions
Author(s) -
Fernando de Carvalho da Silva
Publication year - 2009
Publication title -
revista virtual de química
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.209
H-Index - 14
ISSN - 1984-6835
DOI - 10.5935/1984-6835.20090010
Subject(s) - domino , medicine , oseltamivir , domino effect , virology , chemistry , covid-19 , political science , organic chemistry , law , catalysis , disease , infectious disease (medical specialty)
Esta resenha é sobre a síntese total do (-)-oseltamivir, recentemente publicada por Ishikawa e colaboradores na revista Angewandte Chemie, International Edition. Essa substância é o princípio ativo do medicamento Tamiflu®, poderoso inibidor da enzima neuramidase do vírus da gripe aviária H5N1. Fonte: Ishikawa, H.; Suzuki, T.; Hayashi, Y. Angew. Chem. Int. Ed. 2009, 48, 1304. [CrossRef] DOI: 10.5935/1984-6835.20090010 This digest report the total synyhesis of (-)-oseltamivir (Tamiflu®) by three “one-pot” operations like domino reactions. This article was published by Ishikawa e co-workers in Angewandte Chemie, International Edition. This molecule is a neuraminidase inhibitor used in the treatment against avian H5N1 influenza virus. Source: Ishikawa, H.; Suzuki, T.; Hayashi, Y. Angew. Chem. Int. Ed. 2009, 48, 1304. [CrossRef] DOI: 10.5935/1984-6835.2009001