Open AccessIdentification of sleep fragmentation-induced gut microbiota alteration and prediction of functional impact in Sprague Dawley rats harboring microbiome derived from multiple human donors
Author(s) -
Judy C. Triplett,
Amber Braddock,
Erin Roberts,
David Ellis,
Victor Chan
Publication year - 2022
Publication title -
sleep science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 17
eISSN - 1984-0659
pISSN - 1984-0063
DOI - 10.5935/1984-0063.20200116
Subject(s) - gut flora , microbiome , cecum , ileum , biology , firmicutes , distal colon , microbiology and biotechnology , immunology , bacteria , endocrinology , 16s ribosomal rna , ecology , bioinformatics , genetics
Poor quality sleep, including sleep fragmentation (SF), can result in severe health consequences. Gut microbiota symbiotically coexist with the host, making essential contributions to overall well-being. In this study, the effects of both acute (6-day) and chronic (6-week) SF in a humanized rat model were examined to evaluate the impact of SF on this symbiotic relationship.