Open AccessLong-term outcome of ovarian function after drug-free in vitro activation (IVA) in primary ovarian insufficiency patient
Author(s) -
Janisse Ferreri,
Marta Méndez,
Josep M. Calafell,
Francesc Fàbregues
Publication year - 2021
Publication title -
jbra
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 14
eISSN - 1518-0557
pISSN - 1517-5693
DOI - 10.5935/1518-0557.20200093
Subject(s) - term (time) , drug , medicine , in vitro , premature ovarian insufficiency , pharmacology , chemistry , physics , biochemistry , quantum mechanics
Drug-Free IVA has been recently introduced as a therapeutic option for patients with Primary Ovarian Insufficiency (POI). Despite the existing limited results, it can be considered as a promising option for these patients to achieve their own offspring. Here we report the case of a 35-year-old woman diagnosed with POI at 30 years of age. Drug-Free IVA was performed at age 33 and pregnancy was achieved by IVF 10 months after grafting. Unfortunately, she had a preterm delivery with neonatal death due to prematurity complications. After delivery, she recovered spontaneous ovarian function and one mature oocyte was retrieved 20 months after Drug-Free IVA. Following IVF, one embryo was transferred, and she is currently 33 weeks pregnant, suggesting that Drug-free IVA could lead to long-term ovarian function.