Open AccessCREM, PRM I and II gene expression in Wistar rats testes treated with antipsychotic drugs: Chlorpromazine, Rauwolfia vomitoria and co-administration of reserpine, zinc and ascorbic acid
Author(s) -
Adeleke Opeyemi,
Oyewopo Adeoye,
Adebanji Modupe Akingbade,
Olawumi Johnson
Publication year - 2020
Publication title -
jbra
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 14
eISSN - 1518-0557
pISSN - 1517-5693
DOI - 10.5935/1518-0557.20200058
Subject(s) - reserpine , chlorpromazine , pharmacology , endocrinology , antipsychotic , medicine , reproductive toxicity , toxicity , testosterone (patch) , chemistry , schizophrenia (object oriented programming) , psychiatry
The literature has shown that synthetic antipsychotic drugs induce reproductive toxicity, while psychiatric patients treated with traditionally used antipsychotic herbs (Rauwolfia vomitoria) showed no traces of reproductive toxicity. Thus, this study aimed to investigate the expression of CREM, PRM I and II genes in the testes of Wistar rats treated with antipsychotic drugs: chlorpromazine, Rauwolfia vomitoria (RV) and co-administration of reserpine, zinc and ascorbate (RAZ).