Open AccessIs the risk of preeclampsia higher in donor oocyte pregnancies? A systematic review and meta-analysis
Author(s) -
Juan Enrique Schwarze,
Paula Borda,
Pamela Vásquez,
Carolina Ortega,
Sonia Villa,
Javier Crosby,
Ricardo Pommer
Publication year - 2017
Publication title -
jbra
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 14
eISSN - 1518-0557
pISSN - 1517-5693
DOI - 10.5935/1518-0557.20180001
Subject(s) - preeclampsia , obstetrics , pregnancy , oocyte donation , medicine , in vitro fertilisation , assisted reproductive technology , gynecology , premature ovarian failure , egg donation , oocyte , infertility , biology , embryo , genetics
Preeclampsia (PE) occurs in 4.6% of pregnancies worldwide. The social phenomenon of increasing maternal age has raised the demand for donor oocytes. Egg donation has allowed women with poor ovarian reserve, premature ovarian failure, genetic disorders or surgical menopause to get pregnant. Recipients provide a unique model of immune response because of the differences in the genetic makeup of mothers and fetuses. In PE, immune tolerance may be impaired as a result of having non-autologous eggs implanted. Egg donation is a highly successful assisted reproductive technology, despite the significant number of issues arising from the implantation of non-autologous eggs. This study aimed to determine whether there is an association between egg donation and preeclampsia.