Open AccessPrimary resistance to single and multiple drugs in leprosy-a mouse footpad study
Author(s) -
Shetty Vp,
Uplekar Mw,
Antia Nh
Publication year - 1996
Publication title -
leprosy review
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 43
eISSN - 2162-8807
pISSN - 0305-7518
DOI - 10.5935/0305-7518.19960028
Subject(s) - leprosy , medicine , mycobacterium leprae , lepromatous leprosy , skin biopsy , biopsy , microbiology and biotechnology , immunology , pathology , biology
Skin biopsy homogenates obtained from three cases of lepromatous leprosy with no prior history of antileprosy treatment were tested in the mouse footpad for the sensitivity of Mycobacterium leprae to multiple drugs. One of the inocula was sensitive to all the three drugs tested using the highest concentration each of DDS 0.01 g%, RFP 0.03 g% and CLF 0.01 g%. The 2nd inocula showed growth in the presence of 0.01 g% DDS only. While the 3rd inocula (Pt. KU) tested resistant to all the three drugs in the first, i.e. man to mouse, as well as in the second passage, i.e. mouse to mouse.