Open AccessRessuscitação direcionada ao tempo de enchimento capilar baseada em fenótipo hemodinâmico no choque séptico precoce: protocolo de estudo do ensaio clínico randomizado ANDROMEDA-SHOCK-2
Author(s) -
Eduardo Kattan,
Jan Bakker,
Jan Bakker,
Gustavo Adolfo Ospina-Tascón,
Alexandre Biasi Cavalcanti,
Daniel De Backer,
Antoine VieillardBaron,
JeanLouis Teboul,
Ricardo Castro,
Glenn Hernández
Publication year - 2022
Publication title -
revista brasileira de terapia intensiva
Language(s) - Portuguese
Resource type - Journals
SCImago Journal Rank - 0.431
H-Index - 19
eISSN - 1982-4335
pISSN - 0103-507X
DOI - 10.5935/0103-507x.20220004-pt
Subject(s) - medicine , septic shock , resuscitation , capillary refill , blood pressure , shock (circulatory) , surviving sepsis campaign , pulse pressure , organ dysfunction , anesthesia , hemodynamics , perfusion , intensive care medicine , cardiology , sepsis , severe sepsis
Early reversion of sepsis-induced tissue hypoperfusion is essential for survival in septic shock. However, consensus regarding the best initial resuscitation strategy is lacking given that interventions designed for the entire population with septic shock might produce unnecessary fluid administration. This article reports the rationale, study design and analysis plan of the ANDROMEDA-2 study, which aims to determine whether a peripheral perfusion-guided strategy consisting of capillary refill time-targeted resuscitation based on clinical and hemodynamic phenotypes is associated with a decrease in a composite outcome of mortality, time to organ support cessation, and hospital length of stay compared to standard care in patients with early (< 4 hours of diagnosis) septic shock.