Open AccessACETANILIDE: SOLVENT-FREE GREEN SYNTHESIS
Author(s) -
Sílvio Cunha,
Otelício Bispo dos Santos da Costa,
Leandro D. de Santana,
Wilson Araújo Lopes
Publication year - 2015
Publication title -
química nova
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.214
H-Index - 73
eISSN - 1678-7064
pISSN - 0100-4042
DOI - 10.5935/0100-4042.20150080
Subject(s) - acetanilide , chemistry , organic chemistry
We described herein a solvent-free synthesis of acetanilide developed in the context of green chemistry. The synthetic approach consisted of the reaction of aniline with acetic anhydride without additives, while using smaller amounts of reagents and water than previously described for this undergraduate experiment. The E Factor was 0.6 by experienced chemists and 0.9 by students.