Open AccessPHYSICOCHEMICAL ANALYSES OF MODIFIED CHONDROITIN SULFATE BIOFILMS
Author(s) -
Élcio José Bunhak,
Elisabete Scolin Mendes,
Nehemias Curvelo Pereira,
Edgardo Alfonso Gómez Pineda,
Ana Adelina Winkler Hechenleitner,
Osvaldo Albuquerque Cavalcanti
Publication year - 2015
Publication title -
química nova
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.214
H-Index - 73
eISSN - 1678-7064
pISSN - 0100-4042
DOI - 10.5935/0100-4042.20150030
Subject(s) - chondroitin sulfate , biofilm , sulfate , chemistry , chondroitin , microbiology and biotechnology , geology , biochemistry , biology , bacteria , glycosaminoglycan , organic chemistry , paleontology
Numerous investigations are dedicated to the research and development of new polymer materials destined for innovation in pharmaceutical forms. The application of these technological resources has allowed the commercialization of new therapeutic systems for modified drug release. This investigation aimed to evaluate the association of modified chondroitin sulfate with an insoluble polymer, Eudragit® RS 30 D, widely available in the pharmaceutical market. Isolated films were prepared by the evaporation process using a Teflon® plate. The aqueous dispersions (4% m/v) of synthetic polymer received the addition of modified chondroitin sulfate at different ratios. The interactions of the polymer chains in the blends were physicochemically characterized by means of Fourier transform infrared spectroscopy, thermal analyses, differential scanning calorimetry, thermogravimetry and scanning electron microscopy combined with hydration and assays in alkaline pH. The results showed appropriate properties of the coating materials for solid oral forms intended for drug deliver in specific environments