Open AccessDISTRIBUTION, BIOLOGICAL ACTIVITIES, SYNTHESIS, AND PURIFICATION METHODS FOR PODOPHYLLOTOXIN AND ITS DERIVATIVES
Author(s) -
Héctor Hugo S. Medrado,
Jorge M. David,
Juceni P. David,
Hugo Neves Brandão
Publication year - 2014
Publication title -
química nova
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.214
H-Index - 73
eISSN - 1678-7064
pISSN - 0100-4042
DOI - 10.5935/0100-4042.20140294
Subject(s) - podophyllotoxin , distribution (mathematics) , computational biology , chemistry , combinatorial chemistry , biology , mathematics , stereochemistry , mathematical analysis
Podophyllotoxin is the most studied lignan because of its use as an antimitotic agent and because it is a precursor of pharmacologically active derivatives. This review describes the anticancer activities of podophyllotoxin and the different processes that have been developed for its extraction and purification from Podophyllum spp. In addition, the synthesis routes of this compound and the development of three semi-synthetic procedures to obtain etoposide, teniposide, and Etopophos are detailed