Open AccessIN VITROANTIBACTERIAL ACTIVITY AND TOXICITY TOWARDArtemia salinaLeach. OF SOME TRIAZENE COMPOUNDS
Author(s) -
Gustavo Luiz Paraginski,
Claiton Roberto Berticelli,
Priscilla J. Zambiazi,
Vanessa Teixeira Kunz Paraginski,
Manfredo Hörner,
Aline Joana Rolina Wohlmuth Alves dos Santos,
Rosmari Hörner
Publication year - 2014
Publication title -
química nova
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.214
H-Index - 73
eISSN - 1678-7064
pISSN - 0100-4042
DOI - 10.5935/0100-4042.20140180
Subject(s) - artemia salina , triazene , antibacterial activity , in vitro , toxicity , biology , chemistry , pharmacology , microbiology and biotechnology , biochemistry , bacteria , organic chemistry , genetics
Bacterial resistance to antibacterial agents is currently a major concern. We report the synthesis, in vitro antibacterial activity and toxicity toward Artemia salina of six diaryltriazene compounds bearing different substituent groups. Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) values against standard strains (ATCC) and clinical isolates (including ESBL, MBL and AmpC strains) were good to very good, in the range 8 to 128 mg mL-1. Results suggest that hydroxyl, 4-carboxyl and 4-phenyldiazenil groups attached to the diaryltriazenes provide enhanced activity. Toxicity results showed very low LC50 values for three compounds (10-fold lower than DTIC)