Open AccessCHEMICAL STUDY AND ANTIPROLIFERATIVE, TRYPANOCIDAL AND LEISHMANICIDAL ACTIVITIES OFMaxillaria picta
Author(s) -
Thiago L. de Almeida,
Josiane A. Monteiro,
Greice K.P. Lopes,
Lucas Ulisses Rovigatti Chiavelli,
Silvana Maria de Oliveira Santin,
Cleuza C. da Silva,
Vanessa Kaplum,
Débora B. Scariot,
Celso V. Nakamura,
Ana Lúcia Tasca Góis Ruiz,
João Ernesto de Carvalho,
Ricardo Tadeu de Faria,
Armando M. Pomini
Publication year - 2014
Publication title -
química nova
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.214
H-Index - 73
eISSN - 1678-7064
pISSN - 0100-4042
DOI - 10.5935/0100-4042.20140179
Subject(s) - xanthone , terpene , trypanosoma cruzi , chemistry , traditional medicine , stereochemistry , biology , medicine , parasite hosting , world wide web , computer science
The chemical study of the orchid Maxillaria picta resulted in the isolation of the bioactive stilbenes phoyunbene B and phoyunbene C, in addition to four phenolic acids, one xanthone, steroidal compounds and two triterpenes. Crude extract, fractions, subfractions and the isolated xanthone were evaluated for anticancer activity against human tumor cell lines and against evolutionary forms of T. cruzi and L. amazonensis. The structures of the compounds were determined by GC-MS, and 1H NMR, 13C NMR spectral methods as well as bidimensional techniques