Open AccessThe nuclear factor E2-related factor 2 and age-related macular degeneration
Author(s) -
Rogil José de Almeida Torres,
Rogério João de Almeida Torres,
Andréa Luchini,
Ana Lúcia dos Anjos Ferreira
Publication year - 2022
Publication title -
arquivos brasileiros de oftalmologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.603
H-Index - 29
eISSN - 1678-2925
pISSN - 0004-2749
DOI - 10.5935/0004-2749.20230024
Subject(s) - macular degeneration , degeneration (medical) , vascular endothelial growth factor , risk factor , medicine , growth factor , ophthalmology , pathology , vegf receptors , receptor
After the discovery of anti-vascular endothelial growth factor agents as treatment of wet age-related macular degeneration, the number of studies with the objective to understand the molecular mechanisms involved in the age-re lated macular degeneration genesis has increased. The importance of the nuclear factor e2-related factor 2 lies in its activation-derived proteins being involved in the maintenance of the redox balance and consequent prevention of degenerative macular disease. This article aims to present the characteristics of nuclear factor e2-related factor 2 and describe the main nuclear factor e2-related factor 2-activated antioxidant enzymes that contribute to the preservation of vision.