Open AccessAnti-fibrotic effects of rosmarinic acid on Tenon’s capsule fibroblasts stimulated with TGF-β: therapeutic potential in ocular surgery
Author(s) -
Carolina Maria Módulo,
Larissa Domenegueti Ferreira,
Lilian Eslaine Costa Mendes da Silva,
Marco Andrey Cipriani Frade,
Peter S. Reinach,
Eduardo Melani Rocha,
Jayter Silva Paula
Publication year - 2020
Publication title -
arquivos brasileiros de oftalmologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.603
H-Index - 29
eISSN - 1678-2925
pISSN - 0004-2749
DOI - 10.5935/0004-2749.20200042
Subject(s) - rosmarinic acid , hydroxyproline , mortise and tenon , myofibroblast , transforming growth factor , capsule , fibroblast , chemistry , cell growth , viability assay , microbiology and biotechnology , cell , pathology , biochemistry , medicine , biology , fibrosis , antioxidant , in vitro , botany , structural engineering , engineering
Collagen deposition and myofibroblast differentiation are critical factors related to excessive scarring in ocular surgeries. This study evaluated the anti-fibrotic activity of rosmarinic acid on rabbit Tenon's capsule fibroblasts stimulated with transforming growth factor- β2.