Anti-fibrotic effects of rosmarinic acid on Tenon’s capsule fibroblasts stimulated with TGF-β: therapeutic potential in ocular surgery | Zendy

Carolina Maria Módulo | Zendy; Larissa Domenegueti Ferreira | Zendy; Lilian Eslaine Costa Mendes da Silva | Zendy; Marco Andrey Cipriani Frade | Zendy; Peter S. Reinach | Zendy; Eduardo Melani Rocha | Zendy; Jayter Silva Paula | Zendy

Open Access

Anti-fibrotic effects of rosmarinic acid on Tenon’s capsule fibroblasts stimulated with TGF-β: therapeutic potential in ocular surgery

Author(s) -

Carolina Maria Módulo,

Larissa Domenegueti Ferreira,

Lilian Eslaine Costa Mendes da Silva,

Marco Andrey Cipriani Frade,

Peter S. Reinach,

Eduardo Melani Rocha,

Jayter Silva Paula

Publication year - 2020

Publication title -

arquivos brasileiros de oftalmologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.603

H-Index - 29

eISSN - 1678-2925

pISSN - 0004-2749

DOI - 10.5935/0004-2749.20200042

Subject(s) - rosmarinic acid , hydroxyproline , mortise and tenon , myofibroblast , transforming growth factor , capsule , fibroblast , chemistry , cell growth , viability assay , microbiology and biotechnology , cell , pathology , biochemistry , medicine , biology , fibrosis , antioxidant , in vitro , botany , structural engineering , engineering

Collagen deposition and myofibroblast differentiation are critical factors related to excessive scarring in ocular surgeries. This study evaluated the anti-fibrotic activity of rosmarinic acid on rabbit Tenon's capsule fibroblasts stimulated with transforming growth factor- β2.

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