Open AccessLong-term treatment with 3,4-methylenedioxymethamphetamine caused retina damage in C57BL/6 mice
Author(s) -
Xiang-Qin Liu,
Hong Ye
Publication year - 2019
Publication title -
arquivos brasileiros de oftalmologia
Language(s) - English
Resource type - Journals
eISSN - 1678-2925
pISSN - 0004-2749
DOI - 10.5935/0004-2749.20190070
Subject(s) - retinal , retina , electroretinography , pharmacology , intraperitoneal injection , dopamine , serotonin , oxidative stress , neurotoxicity , medicine , endocrinology , biology , toxicity , neuroscience , ophthalmology , receptor
As a class of psychostimulant drugs, amphetamines are widely abused for their stimulant, euphoric, and hallucinogenic properties. Many of these effects result from acute increases in dopamine and serotonin neurotransmission. Following the onset of these effects, 3,4 methylenedioxymethamphetamine produces persistent damage to dopamine and serotonin nerve terminals, resulting in long-lasting neurotoxicity. The purpose of this investigation was to assess the effects of treatment with low dose of methylenedioxymethamphetamine on retinal function of C57BL/6 mice and its underlying mechanisms.