Open AccessStability Determination of an Extemporaneously Compounded Ambrisentan Suspension by High Performance Liquid Chromatography Analysis
Author(s) -
Jesse Cramer,
Mackenzie Bevry,
Stephanie S. Handler,
Kathryn Harker Tillman,
Ehab A. Abourashed
Publication year - 2021
Publication title -
the journal of pediatric pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 15
eISSN - 2331-348X
pISSN - 1551-6776
DOI - 10.5863/1551-6776-26.3.265
Subject(s) - ambrisentan , chromatography , high performance liquid chromatography , bottle , chemistry , medicine , materials science , endothelin receptor , receptor , bosentan , composite material , biochemistry
Ambrisentan, an endothelin receptor antagonist FDA-approved for the treatment of pulmonary arterial hypertension in adult patients, lacks an acceptable pediatric dosage form. The objective of this investigation was to determine the stability of an extemporaneously compounded ambrisentan suspension.