Open AccessSuspected Overlap Between Serotonin Syndrome and Neuroleptic Malignant Syndrome in a Child Treated With Metoclopramide?
Author(s) -
M. Aussedat,
Annie Lavoie,
Jean-François Bussières,
Niina Kleiber
Publication year - 2020
Publication title -
the journal of pediatric pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 15
eISSN - 2331-348X
pISSN - 1551-6776
DOI - 10.5863/1551-6776-25.6.552
Subject(s) - metoclopramide , neuroleptic malignant syndrome , serotonin syndrome , hypertonia , medicine , clonus , anesthesia , serotonin , pediatrics , psychiatry , vomiting , epilepsy , receptor , serotonergic
A 19-month-old child presented with fever and acute neurological deterioration with hypertonia, tremors, and clonus 1 day after starting metoclopramide. The clinical course of the patient was suggestive of neuroleptic malignant syndrome (NMS) and serotonin syndrome (SS), which can both be triggered by metoclopramide. This first pediatric report of an overlap between NMS and SS associated to metoclopramide highlights the importance of considering this new entity and its consequences on treatment.