Open AccessDevelopment and Validation of Weight, Height and Age Bands to Guide the Prescription of Fixed-Dose Dispersible Tablet Formulations
Author(s) -
Charles P. Larson,
Laura Sauvé,
Jude Senkungu,
Shams El Arifeen,
Rollin Brant
Publication year - 2015
Publication title -
the journal of pediatric pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 15
eISSN - 2331-348X
pISSN - 1551-6776
DOI - 10.5863/1551-6776-20.1.24
Subject(s) - medicine , artemether , percentile , therapeutic index , body weight , pediatrics , anthropometry , drug , mathematics , pharmacology , statistics , artemisinin , plasmodium falciparum , malaria , immunology
Conversion of pediatric essential drugs from syrup to dispersible tablet formulations would require fixed dose options guided by the weight band in which a child falls or a proxy for weight, such as height or age. The purpose of this study was to determine whether weight, height, or age bands can be created that would lead to greater than 95% of children receiving a therapeutic dose of 6 commonly prescribed essential drugs, including paracetamol, iron sulfate, amoxicillin, co-trimoxazole (i.e., trimethoprim/sulfamethoxazole), ciprofloxacin, and co-artemether (i.e., artemether/lumefantrine).