Open AccessVoriconazole Monitoring in Children with Invasive Fungal Infections
Author(s) -
Lyn Tucker,
Tara Higgins,
Eric F. Egelund,
Baiming Zou,
Vini Vijayan,
Charles A. Peloquin
Publication year - 2015
Publication title -
the journal of pediatric pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 15
eISSN - 2331-348X
pISSN - 1551-6776
DOI - 10.5863/1551-6776-20.1.17
Subject(s) - voriconazole , medicine , therapeutic drug monitoring , trough concentration , therapeutic index , toxicity , trough level , surgery , gastroenterology , dosing , drug , pharmacology , pharmacokinetics , transplantation , antifungal , dermatology , tacrolimus
The primary objective of this study was to determine the optimal daily dose of voriconazole required to achieve therapeutic trough concentrations in children 1 month to 18 years of age. The secondary objective was to analyze the association between voriconazole trough concentrations and clinical and microbiological outcomes, toxicity, and mortality.