Open AccessVancomycin Dosing in Healthy-Weight, Overweight, and Obese Pediatric Patients
Author(s) -
Lea S. Eiland,
Kalyani Sonawane
Publication year - 2014
Publication title -
the journal of pediatric pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 15
eISSN - 2331-348X
pISSN - 1551-6776
DOI - 10.5863/1551-6776-19.3.182
Subject(s) - dosing , overweight , medicine , vancomycin , trough concentration , pharmacokinetics , obesity , gastroenterology , biology , bacteria , genetics , staphylococcus aureus
With an increase in vancomycin resistance and the prevalence of obesity in children, alterations of vancomycin dosing regimens may be necessary to achieve target serum concentrations. The primary objective of this study was to describe initial vancomycin dosing with resulting serum concentrations in healthy-weight and overweight/obese children. Secondary objectives include comparing vancomycin dosing regimens of healthy-weight and overweight/obese patients that produced target trough serum concentrations and evaluating the likelihood of attaining target concentrations by patient characteristics.