Open AccessEvaluation of Serum Concentrations Achieved With an Empiric Once-Daily Tobramycin Dosage Regimen in Children and Adults With Cystic Fibrosis
Author(s) -
Heather L. VandenBussche,
Douglas N. Homnick
Publication year - 2012
Publication title -
the journal of pediatric pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.456
H-Index - 15
eISSN - 2331-348X
pISSN - 1551-6776
DOI - 10.5863/1551-6776-17.1.67
Subject(s) - tobramycin , regimen , medicine , cystic fibrosis , dosing , adverse effect , pharmacodynamics , spirometry , aminoglycoside , pharmacokinetics , anesthesia , asthma , antibiotics , gentamicin , chemistry , biochemistry
To assess the ability of an empiric once-daily dosing (ODD) tobramycin regimen to achieve desired serum concentrations in patients with cystic fibrosis (CF); to determine an optimal dosage regimen, using pharmacodynamic parameters; and to evaluate clinical response, adverse effects, and patient/parent satisfaction with ODD.