Open AccessComparison of Nonsequencing Techniques for Identification of NPM1 Mutations and Associated Blast Morphology in Patients With Acute Myeloid Leukemia
Author(s) -
Pâmela Rossi Menegotto,
Mariela Granero Farias,
Fabiane Spagnol,
Marina Siebert,
Eduardo Cremonese Filippi-Chiela,
Ana Paula Alegretti,
Diogo André Pilger
Publication year - 2022
Publication title -
archives of pathology and laboratory medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.79
H-Index - 117
eISSN - 1543-2165
pISSN - 0003-9985
DOI - 10.5858/arpa.2021-0601-oa
Subject(s) - npm1 , myeloid leukemia , nucleophosmin , polymerase chain reaction , mutation , biology , leukemia , flow cytometry , microbiology and biotechnology , cancer research , genetics , gene , karyotype , chromosome
Nucleophosmin 1 (NPM1) mutations affect 20% to 30% of all acute myeloid leukemia (AML) patients; several methods are employed to analyze NPM1 mutations, each of them with its advantages and limitations.