Open AccessMolecular Signatures of Pancreatic Cancer
Author(s) -
Seung Mo Hong,
Jason Park,
Ralph H. Hruban,
Michael Goggins
Publication year - 2011
Publication title -
archives of pathology and laboratory medicine
Language(s) - English
Resource type - Journals
eISSN - 1543-2165
pISSN - 0003-9985
DOI - 10.5858/2010-0566-ra.1
Subject(s) - pancreatic cancer , intraductal papillary mucinous neoplasm , pancreatic intraepithelial neoplasia , context (archaeology) , epigenome , pathology , adenocarcinoma , pancreas , cancer , molecular pathology , pancreatic disease , cancer research , biology , pancreatic ductal adenocarcinoma , medicine , dna methylation , gene , genetics , paleontology , gene expression
The introduction of genome- and epigenome-wide screening techniques has dramatically improved our understanding of the molecular mechanisms underlying the development of pancreatic cancer. There are now 3 recognized histologic precursors of pancreatic cancer: pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. Each of these precursor lesions is associated with specific molecular alterations.