Open AccessValidation of the circulating monocyte being representative of the cholesterol-loaded macrophage: biomediator activity.
Author(s) -
Sridevi Devaraj,
Ishwarlal Jialal
Publication year - 2008
Publication title -
pubmed
Language(s) - English
Resource type - Journals
ISSN - 0003-9985
DOI - 10.5858/2008-132-1432-votcmb
Subject(s) - monocyte , macrophage , cd14 , hyperlipidemia , cholesterol , medicine , endocrinology , inflammation , tumor necrosis factor alpha , integrin alpha m , interleukin , superoxide , interleukin 6 , immunology , cytokine , chemistry , biochemistry , in vitro , receptor , diabetes mellitus , enzyme
Inflammation is pivotal to atherosclerosis. The monocyte-macrophage, a crucial cell in atherogenesis, is present during all stages of atherosclerosis. However, there is a paucity of data comparing circulating monocytes to cholesterol-laden macrophages (foam cells), with regard to their atherogenic properties, especially in subjects with established risk factors such as hyperlipidemia.