Open AccessEffects of dynamic ventilatory factors on ventilator-induced lung injury in acute respiratory distress syndrome dogs
Author(s) -
Ruilan Wang,
Kan Xu,
Kaijiang Yu,
Xue Tian,
Hui Xie
Publication year - 2012
Publication title -
world journal of emergency medicine
Language(s) - English
Resource type - Journals
ISSN - 1920-8642
DOI - 10.5847/wjem.j.issn.1920-8642.2012.04.009
Subject(s) - ards , medicine , lung , atelectasis , mechanical ventilation , diffuse alveolar damage , acute respiratory distress , respiratory distress , tidal volume , pathology , respiratory system , gastroenterology , anesthesia
Mechanical ventilation is a double-edged sword to acute respiratory distress syndrome (ARDS) including lung injury, and systemic inflammatory response high tidal volumes are thought to increase mortality. The objective of this study is to evaluate the effects of dynamic ventilatory factors on ventilator induced lung injury in a dog model of ARDS induced by hydrochloric acid instillation under volume controlled ventilation and to investigate the relationship between the dynamic factors and ventilator-induced lung injuries (VILI) and to explore its potential mechanisms.