Open AccessRenal denervation: dark past, bright future?
Author(s) -
Marshall Heradien,
Felix Mahfoud,
Doug A. Hettrick,
Paul A. Brink
Publication year - 2019
Publication title -
cardiovascular journal of south africa/cardiovascular journal of southern africa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.378
H-Index - 35
eISSN - 1680-0745
pISSN - 1015-9657
DOI - 10.5830/cvja-2019-045
Subject(s) - denervation , medicine , autonomic nervous system , cardiology , sympathetic nervous system , sympathectomy , peripheral , heart rate , blood pressure
The purpose of this review is to update the reader on the relevance of autonomic nervous system imbalance in clinical cardiology. Increased sympathetic tone associates with the metabolic syndrome, hypertension and cardiac arrhythmias. With the kidneys playing a pivotal role in increased peripheral resistance, sodium and water retention and other mechanisms, renal denervation (RD) may theoretically restore autonomic imbalance and improve cardiovascular outcomes. Landmark RD trials and novel uses for RD in cardiac arrhythmia management are discussed.