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Significance of Primary Melanoma Regression on Local Infiltrate and Outcome
Author(s) -
Awatef Kelati,
B. Balme,
B Chouvet,
Alexandra TraverseGlehen,
Juliette Tantot,
Olivier Harou,
Gérard Duru,
S. Debarbieux,
Stéphane Dalle,
Luc Thomas
Publication year - 2022
Publication title -
dermatology practical and conceptual
Language(s) - English
Resource type - Journals
ISSN - 2160-9381
DOI - 10.5826/dpc.1201a34
Subject(s) - medicine , regression , proportional hazards model , melanoma , pathology , regression analysis , oncology , cancer research , psychology , machine learning , computer science , psychoanalysis
The characteristics and the prognostic value of regression in primary melanomas are controversial.Objectives: To further characterize “hot” and “cold” tumor’s stromas and to investigate the association between dermoscopy, pathology, and the prognostic implications of regression.Methods: A 14-year-collection-based retrospective analysis was carried out on 40 patients with confirmed regressive melanomas.Results: The extent of regression in dermoscopy was associated with the stage of the regression (P = 0.05) and with the MelanA patterns in histology (P = 0.02). Blue-gray and gray-brown color of the peppering (P = 0.01), and  the eccentric, multifocal character of the dermoscopic regression (P = 0.05) were associated with “hot” stromas (CD8+, Granzym B+). Focal histologic regression (regressing melanomas) was associated with a good outcome (P < 0.001), while a complete regression (regressed melanomas) was associated with melanoma-related death (P < 0.001). “Hot” stromas (CD8+ were significantly associated with survival at 10 years (P = 0.044), while “hot” stromas (Granzyme B+) were associated with the locoregional extension (P = 0.016), and the initial distant metastasis (P = 0.016).Conclusions: Dermoscopic features of regression in primary melanomas were associated with the stage of regression, its extent, and the “hot” or “cold” nature of the tumor stroma, with prognostic implications.

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