Open AccessHuman Cytomegalovirus and Human Herpesvirus-6 and Wilms Tumor: Is There a Link?
Author(s) -
Maryam Kazemi Aghdam,
Seyed Alireza Nadji,
Maliheh Khoddami,
Mohamad Mahdi Tehrani
Publication year - 2020
Publication title -
archives of pediatric infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 12
eISSN - 2322-1836
pISSN - 2322-1828
DOI - 10.5812/pedinfect.103904
Subject(s) - human cytomegalovirus , medicine , polymerase chain reaction , nested polymerase chain reaction , virology , cytomegalovirus , wilms' tumor , autopsy , virus , real time polymerase chain reaction , kidney , pathology , herpesviridae , viral disease , gene , biology , genetics
Background: Identifying etiologic factors contributing to Wilms tumor (WT) is necessary for its prevention and treatment. Oncogenic viruses cause nearly 20% of all human cancers. Although trials on preventing virus-caused cancers are complex and difficult, but they are not impossible to conduct. Human Cytomegalovirus (HCMV) and human herpes virus-6 (HHV6) can cause different types of cancers. Objectives: The current study aimed to investigate whether HCMV and HHV6-DNA are present in patients with WT. This is the first study of this kind in Iran. Methods: This study was performed on patients with kidney disorders who were referring to Mofid Pediatrics Hospital, Tehran (Iran), during 2010-16. In total, 98 kidney samples (49 patients with WT and 49 normal kidneys (autopsy) and kidneys with benign noninfectious lesions) were investigated to identify HCMV and HHV6-DNA. Qualitative Polymerase Chain reaction (PCR) method and nested polymerase chain reaction (nested-PCR) technique were used to identify HCMV and HHV6, respectively. Results: No significant difference was found between WT patients and controls concerning the HCMV or HHV6. Conclusions: Based on the findings, it can be concluded that there is no association between these viruses and WT.