Open AccessIL-10 -1082 A/G (rs1800896) Polymorphism is Effective in Clearing Hepatitis B Virus Infection
Author(s) -
Neda Mahavar,
Mohsen Naseri,
Gholamreza Anani Sarab,
Mohammad Fereidouni,
Masood Ziaee,
Hamidreza Safari,
Mohammad Sadegh Naghizadeh,
Abdolghader Tane,
Roya Mahdavi
Publication year - 2021
Publication title -
jundishapur journal of microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.281
H-Index - 29
eISSN - 2008-4161
pISSN - 2008-3645
DOI - 10.5812/jjm.93003
Subject(s) - hepatitis b virus , medicine , genotype , hepatitis b , restriction fragment length polymorphism , virology , single nucleotide polymorphism , immunology , allele , viral load , virus , biology , gene , genetics
Background: Hepatitis B Virus (HBV) is a universal health challenge all around the world. Several factors like viral load, genetic characteristics, age, sex, and immune status contribute to variable clinical outcomes of HBV infection. The sequels of HBV infection vary remarkably among persons ranging from the spontaneous deletion of infection to persistent infection. Objective: The present study aimed to evaluate the association of single nucleotide polymorphisms IL10-1082 with HBV clearance. Methods: Sixty subjects with Chronic Hepatitis B (CHB) infection and 60 subjects who spontaneously recovered HBV were enrolled in the study. The IL-10-1082 polymorphisms were determined by Polymerase Chain Reaction with Restriction Fragment Length Polymorphism (PCR–RFLP). Results: The clearance of HBV infection demonstrated a significant association with IL-10-1082 polymorphisms in the GG genotype (P = 0.03), while there was no association with other genotypes. Reduced risk of chronic hepatitis B infection was associated with IL-10-1082 GG (OR: 2.33, 95% CI: 1.07 - 5.09). Besides, IL-10-1082 A/G alleles did not differ clearly between the two study groups (P = 0.07) Conclusions: The IL-10-1082 polymorphisms may be associated with a reduced risk of CHB infection and recovery after HBV infection.