Open AccessOvarian Drilling Efficacy, Estradiol Levels and Pregnancy Rate in Females With Polycystic Ovary Syndrome
Author(s) -
Farideh Moramezi,
Roshan Nikbakhat,
Azam Rafigh
Publication year - 2015
Publication title -
jentashapir journal of health research
Language(s) - English
Resource type - Journals
ISSN - 2345-4067
DOI - 10.5812/jjhr.27171
Subject(s) - polycystic ovary , anovulation , medicine , ovulation , pregnancy rate , pregnancy , infertility , ovary , population , gynecology , endocrinology , hormone , biology , insulin , insulin resistance , genetics , environmental health
BackgroundPolycystic ovary syndrome (PCOS) is the most common cause of oligoovulation and anovulation in general population and in females with infertility.ObjectivesThe purpose of this study was to compare the efficacy of ovarian laparoscopic drilling procedure (LOD) in females with PCOS, resistant to treatment with estradiol (E2) level less than 40 pg/mL versus more than 40 pg/mL.Materials and MethodsFemales with PCOS, resistant to drug for ovary stimulation, were grouped based on the Estradiol levels of ≤ 40 pg/mL (n = 13) and > 40 pg/mL (n = 15). To survey the ovulation, continuing spontaneous ovulation and cumulative pregnancy rate, ovarian laparoscopic drilling was carried out after the analysis of serum E2.ResultsThere was significant difference in the average starting time of ovulation and continuing spontaneous ovulation of cases with PCOS with E2 levels > 40 pg/mL, compared with ones with E2 ≤ 40 pg/mL (P = 0.029, P = 0.05, respectively). Significant differences were also found in pregnancy rates of cases with PCOS with E2 levels > 40 pg/mL compared with ones with E2 ≤ 40 pg/mL (P = 0.05).ConclusionsThis study revealed that LOD in females with PCOS with a serum E2 > 40 pg/mL was sufficient and safe to trigger development of ovarian follicles followed by clinical pregnancy