Open AccessMicroRNAs as Regulatory Elements of Mammalian Spermatogenesis
Author(s) -
F Malekvandfard,
Leila Zare,
Seyedeh Sahar Mortazavi Farsani,
Mahsa Motavaf
Publication year - 2020
Publication title -
journal of human genetics and genomics
Language(s) - English
Resource type - Journals
ISSN - 2588-6479
DOI - 10.5812/jhgg.108116
Subject(s) - spermatogenesis , microrna , biology , male infertility , infertility , regulation of gene expression , gene , computational biology , microbiology and biotechnology , genetics , endocrinology , pregnancy
: In recent decades, infertility is becoming a public health issue. Male spermatogenesis failure has been considered a major contributory factor to infertility. Mammalian spermatogenesis is a well-defined process, requiring highly regulation processes in both transcriptional and the posttranscriptional levels. Discovery of microRNAs (miRNAs or miR) as essential class of gene expression regulators has provided new insights into a multitude of biological processes including spermatogenesis. In current review study, we first provide a short overview of spermatogenesis process, and then focus on recent studies that have elucidated the essential role of miRNAs in different steps of sperm production.