Open AccessParvovirus B19 Infection Is Associated with Autoimmune Thyroid Disease in Adults
Author(s) -
Zahra Heidari,
Maede Jami
Publication year - 2021
Publication title -
international journal of endocrinology and metabolism/international journal of endocrinology and metabolism.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 23
eISSN - 1726-9148
pISSN - 1726-913X
DOI - 10.5812/ijem.115592
Subject(s) - medicine , euthyroid , thyroid , parvovirus , thyroiditis , autoimmune thyroiditis , immunology , autoimmune disease , gastroenterology , graves' disease , thyroid function , anti thyroid autoantibodies , thyroid function tests , antibody , disease , autoantibody , virus
Background: Autoimmune thyroid diseases are the most frequent autoimmune disorders, with a global prevalence of about 10%. Several mechanisms have been proposed to induce autoimmune thyroid responses by infectious agents. In this study, we aimed to evaluate the association between parvovirus B19 infection and autoimmune thyroid disorders. Methods: Adult patients with newly diagnosed Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) and healthy euthyroid controls were recruited. Various clinical and biochemical parameters, including thyroid function tests and serum parvovirus B19 antibody level (IgG), were assessed and compared between the groups. Results: In this study, data from 404 cases with HT, 248 cases with GD, and 480 healthy individuals as a control group were analyzed. The prevalence of parvovirus B19 infection in patients with HT and GD and controls was 61.1%, 58.9%, and 47.1%, respectively. In the group of patients with HT, there was a significant positive correlation between the B19 IgG and TPOAb (r = 0.764, P < 0.001) and TgAb (r = 0.533, P < 0.001). Also, in patients with GD, the B19 IgG had a significant positive correlation with TPOAb (r = 0.779, P < 0.001) and TgAb (r = 0.467, P < 0.001). Conclusions: Parvovirus B19 infection is commonly seen in patients with autoimmune thyroid disorders.